Impact of general anesthesia on the activity of lipids peroxidase oxidation during cardiac surgery for elderly patients

Oleksandr Druzhyna; Oleg Loskutov

Oleksandr Druzhyna State Institution "Ukrainian Health Ministry Heart Institute" http://orcid.org/0000-0002-4853-5755
Oleg Loskutov State institution "Institute of heart of the Ministry of health of Ukraine", 02660, Ukraine, Kiev, Bratislavskaya str., 5A,

Keywords: elderly age, coronary bypass surgery, lipid peroxidation, sevoflurane, propofol.

Abstract

This paper examines lipid peroxidation (LPO) dynamics and antioxidant system(AOS) values in 43 patients (aged 69,11 ± 1,99, with the weight of 83.7 ± 1.15 kg) during coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB).

The use of propofol resulted in the increase of diene conjugates number (DC) by 17.1 ± 0,40% on the background of higher values of malondialdehyde (MDA) 18.4 ± 1,08% relative to previous values. While with the use of sevoflurane an increase of DC level by 30.1 ± 1,88% on the background of MDA decrease by 19,03 ± 1,01% was noticed.

By the end of the operation propofol group showed a decrease in DC values by 20,14 ± 1,93% compared to the previous values and MDA level decrease by 42.8 ± 1,99% on the background of a questionable increase of ceruloplasmin level (CP). While with the use of sevoflurane we could observe DC decrease by 39.1 ± 1,84% compared to the previous values on the background of CP level increase by 28.8 ± 1,82%.

Thus, the anesthetics under study showed differently directed effect on prooxidant and antioxidant systems of the body and a more distinctive effect on the increase of ceruloplasmin antioxidant level was determined with the use of sevoflurane.

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