Preparation, Characterization and Biological Screening of Novel Imidazoles

  • Dr.Purvesh Shah
Keywords: Imidazole, Benzothiazole and Antibacterial and Antifungal activities.

Abstract

The 4-benzylidene-2-(4-methoxyphenyl)oxazol-5(4H)-one (B) has been prepared from cyclo condensation reaction between hippuric acid (A) with p-anisaldehyde. A series of 4-benzylidene-1-(substitued-2-benzothiazolyl)-2-(4-methoxyphenyl)-1H-imidazol-5(4H)-one (D1-6) have been synthesized from 2-amino substituted benzothiazole (C1-6) by condensation reaction with 4-benzylidene-2-(4-methoxyphenyl)oxazol-5(4H)-one (B). The synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR and Mass spectral data. All the compounds were screened for their antibacterial and antifungal activities.

Downloads

Download data is not yet available.

References

Patel, N. B. and Shaikh, F.M.,(2010) “New 4-thiazolidinones of nicotinic acid with 2-amino-6-methylbenzothiazole and their biological activity”,Sci Pharm.,78,753-765.

Ha, S., Koh, T., Ong, S., Lee T. and Sivasothy Y., (2009) “Synthesis of 2-(4- Propyloxyphenyl) benzothiaozle”, Molbank,M609,1-3.

Gupta, S., Ajmera, N., Gautam, N., Sharma, R. and Gauatam, D., (2009) “Novel synthesis and biological activity study of pyrimido [2,1-b] benzothiazoles”,Ind.J Chem.,48B,853-858.

Kumbhare, R.M. and Ingle, V.N., (2009) “Novel synthesis and biological activity study of pyrimido [2,1-b] benzo thiazoles”, Ind J Chem.,48B,996-1000.

Murthi, Y. and Pathak, D.,(2008)“Synthesis and Antimicrobial screening of Substituted 2-Mercapto benzo thiazoles”, J Pharm Res.,7(3),153-155.

Kini, S., Swain, S. and Gandhi, A., (2007) “Synthesis and Evaluation of novel Benzothiazole Derivates against Human Cervical Cancer cell lines”, Ind J Pharm Sci.,Jan-Feb,46-50.

Stanton,H.L.K.,Gambari,R.,Chung,H.C.,Johny,C.O.T.,Filly,C.,Albert,S.C.C.,(2008)“Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines”, Bioorg Med Chem.,16,3626-3631.

Sreenivasa, M., Jaychand, E., Shivakumar, B., Jayrajkumar, K. and Vijaykumar, (2009) “Synthesis of bioactive molecule flurobenzothiazole comprising potent heterocylic moieties for anthelmintic activity”, J., Arch Pharm Sci and Res.,1(2),150-157.

Pattan, S. Suresh,C.Pujar, V. Reddy, V. Rasal V.and Koti, B.,(2005) “Synthesis and antidiabetic activity of 2-amino [5”(4-sulphonylbenzylidine)-2,4-thiazolidinenone]-7-chloro-6-flurobenzothiazole”, Ind J Chem., 44B, 2404-2408.

Husain,A., Drabu,S. and Kumar,N.,(2009) “Synthesis and biological screening of di- and trisubstituted imidazoles”, Acta Pol Pharm-Drug Res,66,243-248.

Tuncbilek, M., Goker, H., Ertan, R., Eryigit, R., Kendi, E. and Altanlar, E., (1997) “Synthesis and antimicrobial activity of some new aniline benzimidazoles”, Arch.Pharm.,330,372-376.

Navarette-Vazquez, G., Cedillo, R., Hernandez-Campos, A., Yepez, L., Hernandez-Luis, F., Valdez, J., Morales, R., Cortes, R., Hernandez, M. and Castillo,R., (2001) “Synthesis and anti parasitic activity of 2-(trifluoromethyl) benzimidazole derivatives”, Bioorg.Med. Chem. Lett.,11,187-190.

Shah, P.J., (2012) “Synthesis and Biological Activity of Novel Imidazole”,Current Trends in Biotechnology and Chemical Research,2(1),45-51.

Shalini, K.,Sharma, P.K. and Kumar, N.,(2010)“Imidazole and its biological activities, A review”,Chem Sin,,36-47.

Published
2015-07-10
How to Cite
Shah, D. (2015). Preparation, Characterization and Biological Screening of Novel Imidazoles. Journal of Progressive Research in Chemistry, 2(1), 54-60. Retrieved from http://scitecresearch.com/journals/index.php/jprc/article/view/184
Section
Articles