Preparation, Characterization and Biological Screening of Novel Imidazoles

Dr.Purvesh Shah

Dr.Purvesh Shah

Keywords: Imidazole, Benzothiazole and Antibacterial and Antifungal activities.

Abstract

The 4-benzylidene-2-(4-methoxyphenyl)oxazol-5(4H)-one (B) has been prepared from cyclo condensation reaction between hippuric acid (A) with p-anisaldehyde. A series of 4-benzylidene-1-(substitued-2-benzothiazolyl)-2-(4-methoxyphenyl)-1H-imidazol-5(4H)-one (D1-6) have been synthesized from 2-amino substituted benzothiazole (C1-6) by condensation reaction with 4-benzylidene-2-(4-methoxyphenyl)oxazol-5(4H)-one (B). The synthesized compounds were characterized by IR, ¹H-NMR, ¹³C-NMR and Mass spectral data. All the compounds were screened for their antibacterial and antifungal activities.

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