Synthesis of a Novel Products of 1, 3, 4 - Oxdiazole Containing Thiozolidine -4-one Derivatives

Abstract

8-(benzyloxy)quinoline-5-carbaldehyde(1)was converted into 2-(8-(benzyloxy)quinolin-5-yl)-3-(4-(trifluoromethyl)phenyl)thiazolidin-4-one (3) by using  conventional   method of  Schiff’s base and cyclised using mercapto acetic acid and anhydrous ZnCl₂ in 1,4 Diaoxane. These intermediate (3) was converted to 2-((5-(4-oxo-3-(4-(trifluoromethyl) phenyl) thiazolidin-2-yl) quinolin-8-yl) oxy) acetohydrazide (6) by using hydrogenolysis and treated with Ethyl bromo acetate and hydrazine hydrate. The intermediate (6) was converted into thiozolidine attached 1,3,4 oxa diazole derivatives  (7a-h) was synthesized  using benzaldehyde analogs and I₂ / K₂CO₃ .and  scaffolds were thoroughly characterized. The thiozoldine attached benzimidazole and benzthiozole, benzoxazole derivatives were synthesized using PPA and characterized.