Synthesis of a Novel Products of 1, 3, 4 - Oxdiazole Containing Thiozolidine -4-one Derivatives

  • Rama Krishna Vellalacheruvu S.K. University, Anantapur, Andhra Pradesh, India GVK Bio Science Pvt. Ltd., IDA, Nacharam, Secundrabad, Telangana, India
  • R. Sai Leela S.K. University, Anantapur, Andhra Pradesh, India
  • Dr L. K. Ravindranath
Keywords: 1, 3, 4, Oxadiazol, Quinolines Thiozolidine-4- One Nucleus, Combi- Flash Chromatography.

Abstract

8-(benzyloxy)quinoline-5-carbaldehyde(1)was converted into 2-(8-(benzyloxy)quinolin-5-yl)-3-(4-(trifluoromethyl)phenyl)thiazolidin-4-one (3) by using  conventional   method of  Schiff’s base and cyclised using mercapto acetic acid and anhydrous ZnCl2 in 1,4 Diaoxane. These intermediate (3) was converted to 2-((5-(4-oxo-3-(4-(trifluoromethyl) phenyl) thiazolidin-2-yl) quinolin-8-yl) oxy) acetohydrazide (6) by using hydrogenolysis and treated with Ethyl bromo acetate and hydrazine hydrate. The intermediate (6) was converted into thiozolidine attached 1,3,4 oxa diazole derivatives  (7a-h) was synthesized  using benzaldehyde analogs and I2 / K2CO3 .and  scaffolds were thoroughly characterized. The thiozoldine attached benzimidazole and benzthiozole, benzoxazole derivatives were synthesized using PPA and characterized.

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Author Biographies

Rama Krishna Vellalacheruvu, S.K. University, Anantapur, Andhra Pradesh, India GVK Bio Science Pvt. Ltd., IDA, Nacharam, Secundrabad, Telangana, India
Department in Chemistry,
R. Sai Leela, S.K. University, Anantapur, Andhra Pradesh, India
Department in Chemistry,

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Published
2017-07-28
How to Cite
Vellalacheruvu, R., Leela, R., & Ravindranath, D. L. (2017). Synthesis of a Novel Products of 1, 3, 4 - Oxdiazole Containing Thiozolidine -4-one Derivatives. Journal of Progressive Research in Chemistry, 5(1), 221-232. Retrieved from http://scitecresearch.com/journals/index.php/jprc/article/view/1197
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Articles