Gender Comparison Of Alpha-Fetoprotein, CD4, Albumin and Some Liver Enzymes in Symptomatic HIV Subjects on Antiretroviral Therapy

  • Ogbodo Emmanuel Chukwuemeka Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, Nigeria
  • Ezeugwunne Ifeoma Priscilla Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Awka, Nigeria
  • Ezeuduji Oluchi Onyinyechukwu Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University, Awka, Nigeria
  • Analike Rosemary Adamma Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
  • Okezie Ogwuegbu Alozie Department of Chemical Pathology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria
  • Onuora Ifeoma Joy Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
  • Okwara Emmanuel Chidiebere Department of Chemical Pathology, College of Health Sciences, Imo State University, Orlu Campus, Nigeria
  • Nnamdi Johnjude Chinonso Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
  • Obi-Ezeani Chikaodili Nwando Department of Chemical Pathology, Chukwuemeka Odumegwu Ojukwu University, Awka
  • Charles Chinedum Onyenekwe Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
Keywords: HIV, CD4 T-cell count, alpha fetoprotein, albumin, liver enzymes, symptomatic HIV infected male and female individuals.

Abstract

The emergence of Human Immunodeficiency Virus (HIV) has remained an issue of global discuss till date as it continues to invade and ravage the world’s population despite the efforts been made globally at tackling the impact of the virus. This is a case controlled study designed to comparatively evaluate the alpha-fetoprotein, CD4+ T-cell count, albumin and some liver enzymes activities in male and female symptomatic HIV subjects on antiretroviral therapy in NAUTH Nnewi, South Eastern Nigeria. A total of seventy one (71) participants who were aged between 18 and 60 years attending the voluntary counseling and testing unit (VCT) and antiretroviral therapy unit (ART) of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi as well as 25 control subjects were randomly recruited for the study    . CD4 count, alpha fetoprotein (AFP), albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase activities were estimated by standard laboratory methods. Results showed no significant differences in the mean values of AFP, CD4 count, albumin, ALT, AST and ALP  compared between male and female symptomatic HIV infected individuals on ART and symptomatic HIV infected male and female subjects NOT on ART (p>0.05) respectively. Also, there was no significant difference in ALT and AST activities when compared between male and female HIV seronegative control (p>0.05) although ALP activity was significantly higher in female control subjects than in males (p=0.01). This revealed no gender specific differences in mean values of alpha fetoprotein, albumin, CD4 T-cell count, and liver enzyme activities between male and female HIV infected symptomatic individuals on antiretroviral therapy and symptomatic HIV infected persons NOT on antiretroviral therapy.

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Published
2021-07-12
How to Cite
Chukwuemeka, O., Priscilla, E. I., Onyinyechukwu, E. O., Adamma, A. R., Alozie, O. O., Joy, O., Chidiebere, O. E., Chinonso, N. J., Nwando, O.-E. C., & Onyenekwe, C. C. (2021). Gender Comparison Of Alpha-Fetoprotein, CD4, Albumin and Some Liver Enzymes in Symptomatic HIV Subjects on Antiretroviral Therapy. Journal of Progressive Research in Biology, 5(1), 17-25. Retrieved from http://scitecresearch.com/journals/index.php/jprb/article/view/2062
Issue
Vol 5 No 1 (2021): JPRB
Section
Articles

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