Identification and assessment of Modifiable and Non-Modifiable risk factors and oxidative stress in pathophysiology of stroke diseases- a review

  • Derouiche Samir Department of Cellular and Molecular Biology, Faculty of Natural Sciences and Life, El Oued University, El Oued 39000, El Oued, Algeria
  • Salem Saadia Department of Cellular and Molecular Biology, Faculty of Natural Sciences and Life, El Oued University, El Oued 39000, El Oued, Algeria
  • Leguemairi Maroua Laboratory of Biodiversity and Application of Biotechnology in the Agricultural Field, Faculty of the Sciences of Nature and Life,University of El Oued, El-Oued 39000, Algeria
Keywords: Stroke, risk factors, oxidative stress, antioxidants.


The aim of this review is the identifying the main factors risk factors and manifesting the role of oxidative stress as factors associated with stroke diseases. It is very difficult to determine the cause of stroke but studies scientists have shown that some characteristics and non-modifiable factors of peoples played a major role in developing strokelike, age, Gender, Race and Heredity. Other modifiable risk factors includehypertension, Heart disease, Diabetes mellitus, Dyslipidemia and Obesity have also been associated with higher stroke incidence. On the other hand, studies support that oxidative stress is directly involved in the genesis and aggressiveness appearance of stroke. However, cerebral dysfunction like Ischaemia would be followed by reperfusion leads to increased production of free radicals which induce also oxidative stress. In conclusion, changing human behavior in life is the first way to prevent stroke disease; on the other hand, we suggest that antioxidants treatment has great benefits in improving patient health and decreasing the vascular complications of stroke.


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How to Cite
Samir, D., Saadia, S., & Maroua, L. (2021). Identification and assessment of Modifiable and Non-Modifiable risk factors and oxidative stress in pathophysiology of stroke diseases- a review. Journal of Progressive Research in Biology, 5(1), 1-11. Retrieved from